Review Volume 8, Issue 10 pp 2290—2307
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis
Figure 6B. Relationship of autophagy levels to vascular aging and atherosclerosis and the role of Sirt1 in the regulation of autophagy. (B) Excess nutrition decreases autophagy initiation via mammalian target of rapamycin complex 1 (mTORC1) activation and reduced function of AMP-activated kinase (AMPK) and Sirt1. Nutrient-sensing pathways that include mTORC1, AMPK and Sirt1 engage in crosstalk with each other through changing of NAD+ level or acetylation/deacetylation of liver kinase B1 (LKB1).