Review Volume 8, Issue 10 pp 2290—2307
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis
Figure 2. Sirt1 regulates NO production. Sirt1 regulates endothelial NO synthase (eNOS) at both the transcriptional and post-transcriptional levels via deacetylation, resulting in the generation of NO for vascular protection. NO also positively regulates Sirt1.