Research Paper Volume 8, Issue 10 pp 2463—2487
Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury
Figure 10. Scheme of the PRG3 action on RhoA-Rock-PIP5K and RasGRF1 signaling in axon growth and neuronal plasticity. There is experimental evidence for two independent functions of PRG3. First, PRG3 interferes with the RhoA-Rock-PIP5K pathway through translocation of the lipid messenger PIP2. This central signal interference affects general downstream neurite growth inhibitors such as myelin-associated molecules such as Nogo-A, LPA and Thrombin. Secondly, interaction of PRG3 with RasGRF1 induces filopodia formation and neuronal plasticity via downstream effectors such as Raf and MEK.