Research Paper Volume 8, Issue 10 pp 2370—2391
A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated
Figure 1. Body size and composition change with age in female and male mice. (A) 4-month-old females were smaller than 20 and 28-month-old females (p < 0.0001 in both cases) but similar to 32-month-old females (p = 2.276). (B) 4-month -old males were smaller than 20, 28 and 32-month-old male mice (p <0.0001, p <0.0001and p = 0.018, respectively). (C) 20-month-old females had a greater percentage of body fat than 4, 28 and 32-month-old female mice (p < 0.0001 in all cases). 4-month -old females had a greater proportion of body fat than 32-month-old females (p = 0.014) but did not differ from 28-month-old females. (D) 4-old males had a greater proportion of fat than either 28 or 32-month-old males (p = .0.036, p < 0.0001, respectively), as did 20-month-old males (p = 0.0003 and p < 0.0001). But 4 and 20-month-old males and 28 and 32-month-old males did not differ (p > 0.999, p = 0.179, respectively). Post-hoc tests subject to Bonferroni correction for multiple comparisons. Body composition sample size: Females n = 20, 20, 30 and 27 for 4, 20, 28 and 32 months; Males n = 22, 22, 32 and 30 for 4, 20, 28 and 32 months.