Review Volume 8, Issue 10 pp 2264—2289
The role of hydrogen sulfide in aging and age-related pathologies
Figure 3. Overview of the effects of physiological levels of H2S on the Hallmarks of Aging. Hydrogen sulfide affects at least one pathway involved in almost all hallmarks of aging. A direct effect of H2S on pathways involved in telomere attrition was not shown, however the effects of H2S on genome stability might also be beneficial for telomere maintenance, by protecting the integrity of the genome. This is indicated by the interrupted line between H2S and telomere attrition. Physiological levels of H2S were shown to prevent the dysregulation of the pathways associated with aging.