Research Paper Volume 8, Issue 7 pp 1485—1512

Figure 5. Heat map of correlations between modules and HD status in different lobes. The rows correspond to modules found in a consensus module analysis across three lobes (frontal lobe, occipital lobe, parietal lobe). Each module (eigenvector) was correlated to HD status and to the proportion of neurons in the respective brain regions using a robust correlation test (biweight midcorrelation). Columns 2-4 in each panel report the robust correlation coefficients and the corresponding p-value (underneath the correlation coefficient) in the frontal, occipital, and parietal lobe, respectively. Each cell is color-coded according to the sign and strength of the correlation coefficient as shows in the color legend at the right hand side. Stouffer's meta analysis method was used to combine the three robust correlation test statistics across the three lobes. The first column of each panel presents a meta analysis Z statistic for HD status (Stouffer's method applied to the results from the 3 lobes) and corresponding p-value. The remaining columns present analogous results for the estimated proportion of neurons.