Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

Pasquale Picone; Silvia Vilasi; Fabio Librizzi; Marco Contardi; Domenico Nuzzo; Luca Caruana; Sara Baldassano; Antonella Amato; Flavia Mulè; Pier Luigi San Biagio; Daniela Giacomazza; Marta Di Carlo

doi:doi:10.18632/aging.101004

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Research Paper Volume 8, Issue 8 pp 1718—1734

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

Figure 6. Metformin increases the lag-phase duration and reduces the final amount of amyloid fibrils. Aggregation kinetics of 50 μM Aβ_1-40 was followed in the absence (empty circles) and in the presence (black circles) of 2mM metformin by ThT assay. The dye concentration was 12µM.