Research Paper Volume 8, Issue 7 pp 1330—1349

Figure 8. Mitophagy-deficient iPSC colonies are prone to direct differentiation in vivo. Left. Analyses of histopathological features associated with the malignant behavior of iPSC-derived teratomas including the presence of neural rosettes/primitive neural tissues and embryonal carcinoma. Note that small PINK1^−/−-iPSC-derived teratomas lack all the malignant features of iPSCs, which were highly abundant in PINK1^+/+-iPSC-derived teratomas. “-“ means that no features are present, “+” a small number present, “++” a medium number, and “+++” a large number. Right. Representative TEM images of mitochondria in PINK1^+/+- and PINK1^−/−-iPSC-derived teratomas. While the mitochondria in many tissue sections from PINK1^+/+-iPSCs-derived teratomas were characterized by a punctate, perinuclear arrangement, an electron-lucid matrix and poorly developed cristae, mitochondria in the majority of tissue sections from PINK1^−/−-iPSC-derived teratomas formed more developed networks, had an electron-dense matrix and developed cristae. (Nu: Nucleus).