Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

Alejandro Vazquez-Martin; Chris Van Van den Haute; Sílvia Cufí; Bruna Corominas Corominas-Faja; Elisabet Cuyàs; Eugeni Lopez-Bonet; Esther Rodriguez-Gallego; Salvador Fernández-Arroyo; Jorge Joven; Veerle Baekelandt; Javier A. A. Menendez

doi:doi:10.18632/aging.100976

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Research Paper Volume 8, Issue 7 pp 1330—1349

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

Figure 5. α-ketoglutarate is the most impacted metabolite in mitophagy deficient-iPSCs. VIP rank-score of quantified metabolites in the PINK1^+/+- and PINK1^−/−-iPSCs groups. Green box indicates metabolites that achieved VIP scores above 1.0.