Research Paper Volume 8, Issue 5 pp 1064—1078

Figure 3. SIRT6 haploinsufficiency impairs endothelium-dependent vasorelaxation in mice fed high fat diet. (A) Endothelium-dependent vasodilation was determined by relaxation of aortic rings pre-constricted with phenylephrine (PE, 10⁻⁶ mol/L). The dose-response curves of aortic rings to the vasodilator acetylcholine (Ach, 10⁻⁹−10⁻⁵ mol/L) in SIRT6^+/− mice and WT littermates under high fat diet (HFD) conditions for 12 weeks. (B) The dose-response curves of aortic rings to NO donor sodium nitroprusside (SNP, 10⁻⁹−10⁻⁵ mol/L) in SIRT6^+/− mice and WT littermates fed a HFD for 12 weeks. *P<0.05, **P<0.01, compared to WT littermates, n=5-6.