Figure 2.Hippocampal proteomic changes from 12 to 24 monthsThe histogram distribution of the log2 (24-/12-month) protein ratios for the (A) total 1,925 quantified proteins and (B) 126 significantly differentially expressed proteins. (C): Bar graph of overrepresented pathways (p < 0.05) based on the protein list of differentially expressed proteins (from 12 to 24 months, 126 proteins from the Bayes-regularized t-test and multiple hypothesis testing corrections). The upregulated and downregulated refer to the percentage of proteins up (increased expression in 24 compared to 12 months) or downregulated (decreased expression in 24 compared to 12 months) in each pathway.
