N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Dalian Ding; Haiyan Jiang; Guang-Di Chen; Chantal Longo-Guess; Vijaya Prakash Krishnan Muthaiah; Cong Tian; Adam Sheppard; Richard Salvi; Kenneth R. Johnson

doi:doi:10.18632/aging.100927

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Research Paper Volume 8, Issue 4 pp 730—750

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Figure 7. CAP amplitudes greatly reduced in dwg/dwg mice compared to +/+ and +/dwg mice. Mean (+/− SEM, n shown in panels) compound action potential (CAP) input/output functions at 6, 8, 12, 16, 24 and 35 kHz from 6-month-old +/+, +/dwg and dwg/dwg mice. CAP amplitudes in dwg/dwg mice are greatly reduced compared to +/+ and +/dwg mice; amplitudes in +/+ and +/dwg mice are similar. Horizontal dashed line and number indicates the approximate threshold shift (TS) in dwg/dwg mice compared to +/+ mice.