N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Dalian Ding; Haiyan Jiang; Guang-Di Chen; Chantal Longo-Guess; Vijaya Prakash Krishnan Muthaiah; Cong Tian; Adam Sheppard; Richard Salvi; Kenneth R. Johnson

doi:doi:10.18632/aging.100927

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Research Paper Volume 8, Issue 4 pp 730—750

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Figure 1. Dwg/dwg mice develop ARHL. Mean (+/−SEM) auditory brainstem response (ABR) thresholds of +/+, +/dwg and dwg/dwg mice at 1, 3, 6 and 9 months of age at (A) 8 kHz, (B) 16 kHz and (C) 32 kHz. (D) Mean (+/−SEM) ABR threshold shifts of +/dwg and dwg/dwg mice relative to +/+ mice at 1, 3, 6 and 9 months of age at 8, 16 and 32 kHz (n= 29, 29, 26 and 15 for dwg/dwg mice at 1, 3, 6 and 9 months of age; n = 11, 12, 12, 12 for +/+ mice at 1, 3, 6 and 9 months of age and n = 12, 12, 12 and 12 for +/dwg mice at 1, 3, 6 and 9 months of ages).