Figure 1 — N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Research Paper|Volume 8, Issue 4|pp. 730–750

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

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Figure 1.Dwg/dwg mice develop ARHLMean (+/−SEM) auditory brainstem response (ABR) thresholds of +/+, +/dwg and dwg/dwg mice at 1, 3, 6 and 9 months of age at (A) 8 kHz, (B) 16 kHz and (C) 32 kHz. (D) Mean (+/−SEM) ABR threshold shifts of +/dwg and dwg/dwg mice relative to +/+ mice at 1, 3, 6 and 9 months of age at 8, 16 and 32 kHz (n= 29, 29, 26 and 15 for dwg/dwg mice at 1, 3, 6 and 9 months of age; n = 11, 12, 12, 12 for +/+ mice at 1, 3, 6 and 9 months of age and n = 12, 12, 12 and 12 for +/dwg mice at 1, 3, 6 and 9 months of ages).