Research Paper Volume 7, Issue 12 pp 1130—1142

Figure 6. Medication status versus blood cell counts in PD patients. As indicated in the heading of each panel, the panels alternate between the two data sets. Levodopa medication status (x-axis) versus (A,B) proportion of CD8+ T cells, (C,D) naïve CD8+ T cell count, (E,F) exhausted CD+T cell counts (defined as CD8+CD28-CD45RA-), (G,H) proportion of CD4+ T cells, (I,J) naïve CD4+ T cell count, (K,L) proportion of natural killer cells, (M,N) proportion of monocytes, (O,P) granulocytes, (Q,R)B cells, (S,T) plasma blasts (activated B cells). All cell types were estimated based on DNA methylation levels as described in Methods. Each bar plot depicts the mean value (y-axis), 1 standard error, and the group size (underneath the bar). The p-value results from a non-parametric group comparison test (Kruskal Wallis).