Research Paper Volume 4, Issue 9 pp 648—659
Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity
Figure 4. Increased differentiation to T follicular helper cells (Tfh) in aging subjects. A. Bar diagram depicts the percentage of ICOS+, CXCR5+ IL-21+Tfh cells in aged and young CD4+ T cells after activation with IL-12 for 5 days. Data is mean +/− S.E. of 10 different aged and young subjects. B. Contour plot depicts the percent of ICOS+, CXCR5+ IL-21+ Tfh cells in aged and young CD4+ T cells after activation with IL-12 for 5 days. Data is representative of 10 such experiments.