Research Paper Volume 4, Issue 9 pp 648—659
Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity
Figure 1. Increased IL-21 secretion from aged subjects is not due to age-associated alteration in dendritic cell function. A. Bar graph depicts the levels of IL-12p70 in the supernatant from stimulated aged and young DC. B. Bar graph depicts the percent proliferation of aged and young CD4+ T cells after culture with aged DCs. C. Bar graph depicts the level of IL-21 in the supernatant of aged and young CD4+ T cells after culture with aged DCs. D. Bar graph depicts the level of IFN-g in the supernatant of aged and young CD4+ T cells after culture with aged DCs. E. Bar graph depicts the percent proliferation of aged and young CD4+ T cells after culture with young DCs. F. Bar graph depicts the level of IL-21 in the supernatant of aged and young CD4+ T cells after culture with young DCs. G. Bar graph depicts the level of IFN-γ in the supernatant of aged and young CD4+ T cells after culture with young DCs. Data is mean +/− S.E. of 8 different aged and young subjects.