Research Paper Volume 4, Issue 9 pp 620—635

Figure 9. RhTFAM treatment increases brain levels of BDNF and synapsin. Brain levels of proteins assayed by Western blot after treatment of 21 month old mice with rhTFAM once/week for four weeks. Shown are sizes of single rhTFAM doses. Protein levels are normalized to beta-actin and are expressed as % mean CTL. Statistical differences: BDNF (p=0.028 (control v 0.5mg/kg), p=0.029 (control v. 1.5mg/kg), p<0.001 (0.5mg/kg v 1.5mg/kg); PGC-1a (NS); PSD-95 (NS); synapsin (p<0.001 (control v. 1.5mg/kg), p=0.005 (0.5mg/kg v. 1.5mg/kg))