Figure 7. RhTFAM treatment improves State 3 mitochondrial respiration in brain, heart and skeletal muscle. Effects of rhTFAM treatment on state 3 (+ADP) respiration in mitochondrial preparations from brain, heart and muscle in 21 month old mice treated weekly with rhTFAM or buffer CTL, following addition of substrates for Complex I (CI) or Complex IV (CIV). * p<0.05 by paired t-test.