Figure 3.Effects of p19Arf on the cell cycle.In the absence of p19Arf, p53 is ubiquitinized and subsequently degraded by the proteosome. p19Arf inhibits the ubiquitin-modulated effect of p53 by MDM2. p19Arf inhibits ubiquitin-mediated p53 degradation resulting in induction of p21 and subsequently cell cycle arrest. Adapted from [75] and [76]
