Review Volume 3, Issue 6 pp 565—575

Figure 3. Effects of p19^Arf on the cell cycle. In the absence of p19^Arf, p53 is ubiquitinized and subsequently degraded by the proteosome. p19^Arf inhibits the ubiquitin-modulated effect of p53 by MDM2. p19^Arf inhibits ubiquitin-mediated p53 degradation resulting in induction of p21 and subsequently cell cycle arrest. Adapted from [75] and [76]