Research Perspective Volume 3, Issue 4 pp 430—437

Figure 3. Hypothetical model of the effect of age on Sirt1 induction by stretch and its impact on age-associated oxidative stress in diaphragm muscles. Egr1-dependent Sirt1 induction by stretch plays a role in recovering basal ROS levels through the activation of FOXO and increased Sod 2 expression. In the absence of alternative mechanisms of ROS detoxification, the loss of mechanoregulation of Egr1 binding to the Sirt1 promoter and Sirt1 expression in old compared to young diaphragm muscles, may explain the cumulative oxidative damage observed with age. Dashed arrows indicate hypothetical mechanisms.