Research Paper Volume 2, Issue 12 pp 990—998

Figure 4. Therapeutic effect statin in OA mouse model. Each cartilage sample was evaluated histologically for the degree of degeneration, loss of Safranin-O green staining, chondrocyte loss, cartilage structure, according to a modified Mankin grading system (Table 2). At 12 and 24 weeks, severe damage in articular cartilage was observed in each control joint. Treatment with statin induced a significant reduction of cartilage degeneration in comparison with control (* p< 0.05, ** p< 0.01).