Figure 4.Therapeutic effect statin in OA mouse model.Each cartilage sample was evaluated histologically for the degree of degeneration, loss of Safranin-O green staining, chondrocyte loss, cartilage structure, according to a modified Mankin grading system (Table 2). At 12 and 24 weeks, severe damage in articular cartilage was observed in each control joint. Treatment with statin induced a significant reduction of cartilage degeneration in comparison with control (* p< 0.05, ** p< 0.01).
