Chain-breaking antioxidant activity of reduced forms ofmitochondria-targeted quinones, a novel type of geroprotectors

Vitaly A. Roginsky; Vadim N. Tashlitsky; Vladimir P. Skulachev

doi:doi:10.18632/aging.100049

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Research Paper Volume 1, Issue 5 pp 481—489

Chain-breaking antioxidant activity of reduced forms ofmitochondria-targeted quinones, a novel type of geroprotectors

Figure 2. The reduction of SkQ1 by NaBH₄ as studied by UPLC-MS-MS analysis. (A) - Reverse-phase HPLC chromatograms before and after the addition of NaBH₄. (B) - MS/MS spectra of SkQ1 before reduction (at the bottom) and after reduction (at the top). Details of the protocol are given in the text.