Review Volume 1, Issue 2 pp 157—181

Figure 5. Expression of MHC class I heavy chain (MHC-I), CD14 of primitive MDC, CD8 of T cells, and HLA-DR (DR) of activated MDC and T cells, as indicated in the panels, in human fetal ovary obtained at midpregnancy (24 weeks). Asymmetric division (white arrowheads, panels A and B) of OSC (osc) gives rise to the OSC (yellow asterisks) and the germ cell daughters (red asterisks). Symmetric division of germ cells follows (yellow arrowhead, panel B), which is required for crossing over, and the secondary germ cells (sgc) attain the ameboid shape (dashed line, no hematoxylin counterstain) to leave the OSC layer and enter cortex. CD14+ primitive MDC interact with the OSC (arrow, panel C) and accompany (arrowhead, panel D) symmetric division of secondary germ cells. CD8 T cells (panel E) and DR+ cells of lymphocyte type (panel F) accompany (red arrowheads) asymmetric division of OSC (white arrowheads) resulting in emergence of secondary germ cells. DR+ MDC (arrowheads, panel G) associate with growing (gf) but not resting primordial follicles (pf). Bar in C for A-F. Adapted from Ref. [36], © Humana Press.