Figure 3.Immunocytochemical analysis of p16 INK4 in kidneys of 3 month old Ku86+/+ and Ku86-/- mice. Many senescent cells (brown stain) are present in
kidneys of Ku86-/- mice. p16INK4 is higher in the
renal medulla, where salt concentration normally is always high, than in
the cortex, where the salt concentration is similar to that in peripheral
blood. p16INK4 level and staining pattern in kidneys of 3 month
old Ku86-/- mice are similar to those observed previously in 12
month old wild type mice [4].
Figure 3 — Knockout of Ku86 accelerates cellular senescence induced by high NaCl | Aging
