Figure 1 — Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

100%

Figure 1.Maturation of lamin A and formation of progerin or LA∆50.(A) Normal processing of prelamin A. (B) Processing of G608G mutation (C1824T) in HGPS cells. Underline LY (in black) in the deleted 50 AAs: Zmpste24 cleavage site