Figure 4.Repeated BM-INF do not affect fecundity but dramatically improve survival rates of offspring delivered by aging females. Summary of fecundity (mean ±SEM) of female mice that achieved full-term
pregnancies at the indicated ages following once-monthly infusions of vehicle (VEH-INF) or BM harvested from young adult
female donors (BM-INF), starting at 3 months (A) or 8 months (B) of age. (C) Offspring number and survival rates in mating
trials of VEH-INF or BM-INF females between 10-17.5 months of age following once-monthly infusions initiated at 8 months of
age. In addition to a marked increase in the total number of offspring delivered, the number of offspring delivered that
survived was significantly increased by BM-INF (*, P = 0.0001 versus the VEH-INF group by Fisher's exact test).
