Research Paper Volume 16, Issue 20 pp 12955—12976
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
- 1 Institute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, China
- 2 Max Planck Institute for Biology of Ageing, Cologne, Germany
- 3 Institute of Aging Medicine, College of Pharmacy, Binzhou Medical University, Yantai, China
- 4 Anti-aging Innovation Center, Subei Research Institute at Shanghai Jiaotong University, China
- 5 Shandong Cellogene Pharmaceutics Co. LTD, Yantai, China
- 6 Duke Kunshan University, Kunshan, Jiangsu, China
- 7 Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA
- 8 Foresight Institute, San Francisco, CA 91125, USA
- 9 Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
- 10 Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia
- 11 Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK
- 12 Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia
- 13 HautAI OÜ, Tallinn, Estonia
- 14 Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- 15 California Institute of Technology, Pasadena, CA 91125, USA
- 16 Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- 17 Max Delbrück Center for Molecular Medicine, Berlin, Germany
- 18 The Kennedy Institute of Rheumatology, Oxford, UK
- 19 Department of Genetics, Stanford University, Stanford, CA 94305, USA
- 20 Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE
- 21 Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania
- 22 America's Frontier Fund, VA 23320, USA
- 23 Department of Biology, School of Science, Center for Developmental and Regenerative Biology, Indiana University - Purdue University Indianapolis, Indianapolis Indiana 46077, USA
- 24 Centre for Physical Activity Research, Rigshospitalet and University of Copenhagen, Denmark
- 25 Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany
- 26 199 Biotechnologies Ltd., London, UK
- 27 University College London, London, UK
- 28 Molecular, Cellular, And Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA
- 29 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
- 30 Hong Kong Quantum AI Lab, Hong Kong
- 31 Zucker School of Medicine at Hofstra/Northwell, NY 10001, USA
- 32 Charité - University Medicine, Berlin, Germany
- 33 Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA
- 34 Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA
- 35 Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland
- 36 Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
- 37 Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA
- 38 Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA
- 39 Leibniz Institute on Aging, Fritz Lipmann Institute, Friedrich Schiller University, Jena, Germany
- 40 Longevity Center Europe, Warsaw, Poland
- 41 Centre for Psychedelic Research, Dpt Brain Sciences, Imperial College London, UK
- 42 Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02108, USA
- 43 Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
- 44 School of Biology and Environmental Science, Belfield, Univeristy College Dublin, Dublin 4, Ireland
- 45 BioAge Labs, Richmond, CA 94530, USA
- 46 Buck Institute for Research on Aging, Novato, CA 94945, USA
- 47 Research and Early Development, Maaleov 2760, Denmark
- 48 VitaDAO, Ottawa, ON K1V 9K6, Canada
- 49 Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
- 50 Department of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- 51 Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark
- 52 Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen N 2200, Denmark
- 53 European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 54 Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China
- 55 Rejuveron Life Sciences AG, 8952 Schlieren, Switzerland
- 56 Health, Nutrition and Care, DSM-Firmenich, Kaiseraugst, Switzerland
- 57 LongeVC, Riga, Latvia
- 58 InsideTracker, Cambridge, MA 02114, USA
- 59 Department of Psychiatry, Columbia University, New York, NY 10012, USA
- 60 Maxwell Biosciences, Austin, TX 73301, USA
- 61 Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
- 62 Cambrian Bio, Inc., New York, NY 10012, USA
- 63 XPRIZE Foundation, Culver City, CA 90230, USA
- 64 Department of Genetics Albert Einstein College of Medicine, New York, NY 10461, USA
- 65 Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- 66 Life Biosciences, Boston, MA 02116, USA
- 67 Tornado Therapeutics, Cambrian Bio Inc. PipeCo, New York, NY 10012, USA
- 68 Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA
- 69 Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19019, USA
- 70 Retro Biosciences, Inc., Redwood City, CA 94061, USA
- 71 Center on the Biology of Aging, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02860, USA
- 72 Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
- 73 Private Medical, San Francisco, CA 94107, USA
- 74 Faculty of Health Sciences Brandenburg and Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg 01968, Germany
- 75 Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
- 76 Ichor Life Sciences, Inc., LaFayette, NY 13084, USA
- 77 Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- 78 Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55414, USA
- 79 Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
- 80 Nature Biotechnology, Springer Nature, London, UK
- 81 Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21201, USA
- 82 Rubedo Life Sciences, Sunnyvale, CA 94043, USA
- 83 Turn Biotechnologies, Mountain View 94039, CA, USA
- 84 Phaedon Institute, Oakland, CA 94501, USA
- 85 Institute of Biochemistry of the Romanian Academy, Romania
- 86 Fertility and Research Centre, Discipline of Women's Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia
- 87 Longevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA
- 88 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117608, Singapore
- 89 Boston Consulting Group, Boston, MA 02210, USA
- 90 Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany
- 91 Repair Biotechnologies, Inc., Syracuse, NY 13210, USA
- 92 Sapere Bio, Triangle Research Park, NC 27213, USA
- 93 Holmusk, New York, NY 10012, USA
- 94 AniBiome, Zagreb, Croatia
- 95 Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA
- 96 Molecule, Neuhausen am Rheinfall, Switzerland
- 97 Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA
- 98 Gero PTE, Singapore, Singapore
- 99 Insilico Medicine Canada Inc., Montreal, Quebec H3B 4W8 Canada
- 100 Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA
- 101 Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, Maryland 21201, USA
- 102 Huxley Building, School of Applied Sciences, University of Brighton, Brighton, UK
- 103 Biolytica, Zug, Switzerland
- 104 Deciduous Therapeutics, San Francisco, CA 94107, USA
- 105 Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden
- 106 Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany
- 107 Healthspan Capital, El Cerrito, CA 94530, USA
- 108 School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
- 109 Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- 110 Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany
- 111 Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA
- 112 Bioio, Inc., St. Louis, MO 63110, USA
- 113 Collider Heath, London, UK
- 114 Healthy Longevity Champion, National Innovation Centre for Ageing, UK
- 115 Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15106, USA
- 116 Sheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel
- 117 Tel Aviv Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
- 118 Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA
- 119 TruDiagnostic, Lexington, KY 40503, USA
- 120 Department of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA
- 121 Department of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
- 122 Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94301, USA
- 123 Department of Neuro-Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
- 124 Department of Obstetrics and Gynecology, Columbia University, New York City, NY 10032, USA
- 125 Duke University, Durham, NC, USA
- 126 Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany
* Equal contribution
Received: July 3, 2024 Accepted: July 23, 2024 Published: October 16, 2024
https://doi.org/10.18632/aging.206135How to Cite
Copyright: © 2024 Lyu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.