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Research Paper|Volume 16, Issue 17|pp 12209—12224

Genetic effect of thyroid function-related diseases on acute respiratory distress syndrome: a Mendelian randomization study

Peilong Li1,2, Haifeng Liu1,2, Feng Li1, Mingze Sui1,2, Kai Liu1, Hongmin Fu1
  • 1Children’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China
  • 2Department of Pulmonary and Critical Care Medicine, Kunming Children’s Hospital and Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, P.R. China
Received: December 13, 2023Accepted: May 30, 2024Published: July 1, 2024
https://doi.org/10.18632/aging.205996

Copyright: © 2024 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Previous studies have shown an association between acute respiratory distress syndrome (ARDS) and thyroid function. However, their causal relationship remains unspecified. Therefore, this study aims to explore the causal relationship between ARDS and thyroid function-related diseases with Mendelian Randomization (MR) analysis.

Methods: ARDS dataset finn-b-J10_ARDS, finn-b-E4_THYROID dataset of disorders of the thyroid gland (DTG) and finn-b-E4_HYTHYNAS of hypothyroidism were acquired from public database. In univariate MR (UVMR), causal effects between DTG, hypothyroidism and ARDS were investigated using 5 types of algorithms, and reliability was validated by sensitivity analysis. Moreover, multivariate MR (MVMR), enrichment and interaction network analyses of genes corresponding to SNPs of DTG and hypothyroidism were carried out. Significant level was chosen as p<0.05.

Results: UVMR identified DTG and hypothyroidism (P < 0.05, OR > 1) as risk factors, and were causally related to ARDS. Reliability of UVMR results was confirmed through sensitivity analysis, and results were stable and reliable. However, DTG and hypothyroidism had no effect on ARDS in MVMR, possibly because these factors had independent effects on ARDS. Ultimately, 96 and 113 genes corresponding to SNPs of DTG and hypothyroidism were found closely related to immune-related pathways.

Conclusions: UVMR and MVMR analysis revealed a causal connection between DTG and hypothyroidism as risk factors with ARDS, providing robust evidence for investigation into relationship of hypothyroidism on ARDS and between DTG and ARDS.