Research Paper|Volume 15, Issue 18|pp 9809—9821

The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1

Yao Li¹, Xue Meng¹, Yuqing Luo¹, Shuai Luo¹, Jin Li¹, Jiafei Zeng¹, Xiang Huang¹, Jinjing Wang¹

¹Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, P.R. China

Received: May 16, 2023Accepted: August 29, 2023Published: September 21, 2023

https://doi.org/10.18632/aging.205051

Copyright: © 2023 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Lines of evidence have demonstrated that the oncogenic miRNAs are pivotal to the progression of breast cancer. In this study, we investigated the biological traits of microRNA-429 (miR-429) in triple-negative breast cancer (TNBC) and the underlying molecular mechanism. We found that miR-429 was notably overexpressed in TNBC, and promoted TNBC cell proliferation, migration, and invasion by degrading the tumor suppressor DLC1. In conclusion, our findings reveal the mechanism of tumorigenic miR-429 in TNBC, which paves the way for target therapies translation in clinical settings.