Research Paper|Volume 15, Issue 6|pp 1734—1747

Selenium as a predictor of metabolic syndrome in middle age women

Daria Schneider-Matyka¹, Anna Maria Cybulska¹, Małgorzata Szkup¹, Bogumiła Pilarczyk², Mariusz Panczyk³, Agnieszka Tomza-Marciniak², Elżbieta Grochans¹

¹Department of Nursing, Pomeranian Medical University in Szczecin, Szczecin 71-210, Poland
²Department of Animal Reproduction Biotechnology and Environmental Hygiene, West Pomeranian University of Technology, Szczecin 71-217, Poland
³Department of Education and Research in Health Sciences, Faculty of Health Sciences, Medical University of Warsaw, Warsaw 00-581, Poland

Received: December 4, 2022Accepted: March 4, 2023Published: March 21, 2023

https://doi.org/10.18632/aging.204590

Copyright: © 2023 Schneider-Matyka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Selenium plays an important role in metabolic homeostasis. It has been suggested that it may also affect the expression and activity of PPAR-γ. The aim of study was to analyze the relationships between these variables in the context of the health of women, for whom the risk of MetS increases with age.

Material and Methods: The study involved 390 women in middle age. The stages of study: a survey-based part; anthropometric measurements; analysis of biological material (blood) in terms of glycemia, triglyceride, HDL, and selenium levels, as well as genetic analysis of the PPAR-γ polymorphisms.

Results: It was found that selenium may moderate the effect of the G allele of the PPAR-γ gene on the occurrence of elevated waist circumference (OR=1.030, 95%CI 1.005-1.057, p=0.020); and the effect of the C (OR=1.077, 95%CI 1.009-1.149, p=0.026) and the G alleles (OR=1.052, 95%CI 1.025-1.080, p<0.000) on the odds of elevated blood pressure. Women in whom HDL levels were not significantly reduced, had higher selenium levels (p=0.007).

Conclusions: 1. The effect of selenium on MetS and its components has not been demonstrated. 2. The effect of individual alleles of the PPAR-γ gene on MetS and its components was not demonstrated. 3. The concentration of selenium may affect waist circumference in carriers of the G allele, and arterial hypertension in carriers of the C and G alleles by affecting the expression of PPAR-γ. 4. Higher selenium concentrations increased the odds of higher HDL levels in the group of subjects meeting the MetS criteria.