Research Paper|Volume 14, Issue 23|pp 9679—9698

SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma

Yan Pu¹, Jing Han¹, Mengmeng Zhang¹, Mengxue Liu¹, Gulnazar Abdusamat², Huibin Liu^1,³

¹Institute of Cancer Research, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011, PR China
²Department of Pharmacy, Xinjiang Medical University, Urumqi 830011, PR China
³The Clinical Research Center of Breast Tumor and Thyroid Tumor in Xinjiang Autonomous Region, Urumqi 830011, PR China

* Equal contribution

Received: January 30, 2022Accepted: November 19, 2022Published: December 2, 2022

https://doi.org/10.18632/aging.204418

Copyright: © 2022 Pu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The most hostile form of urologic cancer, clear cell renal cell carcinoma (ccRCC), has a high fatality rate and poor prognosis due to tumor metastasis at initial presentation. The complex process driving ccRCC metastasis is still unknown, though. In this study, we demonstrate that Spindle and kinetochore-associated protein 1 (SKA1) expression is significantly upregulated in ccRCC tissues and associated with aggressive clinicopathologic characteristics. Functionally, SKA1 knockdown on ccRCC cells reduced cancer cell motility both in vivo and in vitro research. These bioactivities of SKA1 may be brought on by its specific interaction with scaffold attachment factor B, according to the proposed mechanism (SAFB), which could further depress the transcription of dual specificity phosphatase 6 (DUSP6). Our findings may provide a new way of researching SKA1-regulated tumor metastasis, and indicate that SKA1 is a prospective therapeutic target for renal carcinoma.