Correction|Volume 14, Issue 19|pp 8137—8138

Correction for: Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α

Yan Huang^1,^2,³, Fengbo Tan⁴, Yi Zhuo^1,^2,³, Jianyang Liu⁵, Jialin He⁵, Da Duan^2,³, Ming Lu^1,^2,³, Zhiping Hu⁵

¹Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsh, Hunan, 410081, P.R. China
²Department of Neurosurgery, Second Affiliated Hospital of Hunan Normal University, Changsh, Hunan, 410003, P.R. China
³Hunan Provincial Key Laboratory of Neurorestoration, Second Affiliated Hospital of Hunan Normal University, Changsh, Hunan, 410003, P.R. China
⁴Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsh, Hunan, 410008, P.R. China
⁵Department of Neurology, The Second Xiangya Hospital, Central South University, Changsh, Hunan, 410011, P.R. China

* Equal contribution

Received: August 20, 2022Accepted: September 29, 2022Published: October 14, 2022

https://doi.org/10.18632/aging.204321

Copyright © 2022 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This article has been corrected: The authors requested replacement of Figure 6, in which the images in panel D – production of ROS in BV2 microglial cells in the Normoxia group (the upper right subpanel) and Hypoxia+FG4592 group (the bottom left subpanel) – were incorrectly placed during assembly of the figures. This resulted in duplication of the image of ROS production in the Hypoxia+FG4592 group (P2=1.41%). The authors corrected Figure 6D by using the correct flow cytometry data/image from the original sets of experiments for the Normoxia group (P2=34.68%). This correction does not affect the article's conclusions. The authors would like to apologize for any inconvenience caused.

New Figures 6 is presented below.

Figure 6.

Induction of HIF-1α in OM-MSCs with FG-4592 inhibited cerebral OGD/R-induced apoptosis in BV2 microglial cells. (A, B) The successful overexpression of HIF-1α in OM-MSCs was confirmed by Western blotting. (C, E) The apoptosis rate among BV2 microglial cells was determined with flow cytometry and Annexin V/PI staining in each group. (D, F) Production of ROS levels in BV2 microglial cells was measured with flow cytometry. (G, H) Protein expression of caspase3 in BV2 microglial cells was quantified by Western blotting. (I) The viability of BV2 microglial cells was evaluated with MTT assays. All data are presented as the mean ±SD. *p<0.05; **p<0.01, ***p<0.001, compared to the normoxia or hypoxia group.