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Research Paper|Volume 14, Issue 19|pp 7851—7865

Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients

Tailiang Lu1, Chenglong Li1, Cailing Xiang1, Yongqiang Gong1, Wei Peng1, Futao Hou1, Chaowu Chen1
  • 1Department of General Surgery, Hunan Provincial People’s Hospital, The First-Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, China
Received: May 26, 2022Accepted: August 29, 2022Published: September 22, 2022
https://doi.org/10.18632/aging.204294

Copyright: © 2022 Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Gastric cancer (GC) is the fifth most common cancer worldwide and the third most fatal. Cancer-associated fibroblasts (CAFs) play an essential role in promoting the occurrence and development of gastric cancer in all stages. NFYB is highly expressed in multiple tumors and promotes tumor invasion, metastasis, and drug resistance, but its role in the occurrence and development of gastric cancer remains unclear. Hence, we used TCGA, TIMER, Kaplan-Meier Plot, and UALCAN databases to analyze the expression of NFYB in pan-cancers and assess its clinical prognostic value. We found that high expression of NFYB may be a promising prognostic biomarker in patients with gastric cancer. High expression of NFYB was associated with high T stage, high histological grade, diffuse gastric cancer, and early-onset GC. Moreover, High expression of NFYB was associated with CAFs infiltration in the GC microenvironment. The prognosis of GC patients with high expression of NFYB and high infiltration of CAFs was worse. Therefore, NFYB may serve as a potential prognostic biomarker in patients with GC.