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Research Paper|Volume 13, Issue 23|pp 25025—25037

Serum levels of proinflammatory cytokines and selected bioelements in perimenopausal women with regard to body mass index

Anna Maria Cybulska1, Kamila Rachubińska1, Małgorzata Szkup1, Daria Schneider-Matyka1, Irena Baranowska-Bosiacka2, Dariusz Chlubek2, Anna Lubkowska3, Mariusz Panczyk4, Joanna Sołek-Pastuszka5, Elżbieta Grochans1
  • 1Department of Nursing, Pomeranian Medical University, Szczecin, Poland
  • 2Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
  • 3Department of Functional Diagnostics and Physical Medicine, Pomeranian Medical University, Szczecin, Poland
  • 4Division of Teaching and Outcomes of Education, Faculty of Health Science, Medical University of Warsaw, Warsaw, Poland
  • 5Department of Anaesthesiology and Intensive Therapy, Pomeranian Medical University, Szczecin, Poland
Received: August 24, 2021Accepted: November 24, 2021Published: December 10, 2021
https://doi.org/10.18632/aging.203754

Copyright: © 2021 Cybulska et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

During the menopause, decreased estrogen levels may be accompanied by increased levels of inflammatory mediators. Many studies also show significant relationships between the levels of bioelements and proinflammatory cytokines. The aim of this study was to assess the levels of proinflammatory cytokines, C-reactive protein (CRP), and selected bioelements in perimenopausal women with regard to BMI. Methods: The study of 217 perimenopausal women involved the completion of questionnaires concerning sociodemographic and medical data, anthropometric measurements, and blood collection. Results: In all studied women, the levels of IL-1β significantly positively correlated with Ca, Mg, and Sr; IFNγ significantly negatively correlated with Sr, and IL-6 with Mg. In women with a normal BMI, the levels of IL-1β significantly positively correlated with Ca and Sr, and CRP positively correlated with Zn. In overweight women, the levels of IL-1β positively correlated with Ca, IL-6 with Na, and IFNγ negatively correlated with Sr. In obese women, the levels of CRP positively correlated with Zn, TNFα with Mg, IFNγ with Cu and P. The levels of IL-6 negatively correlated with Ca and Mg. Conclusions: BMI may be one of the factors that affect the relationship between serum bioelement levels and the levels of proinflammatory cytokines and CRP in women, especially during the menopausal period.