Aging
Navigate
Submit an Article
Research Paper|Volume 13, Issue 23|pp 25213—25240

hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP

Jian Liang1, Xing Li3, Jian Xu2, Guang-Mou Cai1, Jian-Xuan Cao1, Bo Zhang1
  • 1The Second Clinical Medical College of Jinan University, Shenzhen People′s Hospital, Shenzhen, China
  • 2Department of Hematology, The Second Clinical Medical College of Jinan University, Shenzhen People′s Hospital, Shenzhen, China
  • 3School of Medicine, Southern University of Science and Technology, Shenzhen, China
Received: February 24, 2021Accepted: November 11, 2021Published: December 12, 2021
https://doi.org/10.18632/aging.203740

Copyright: © 2021 Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Glioma is a primary intracranial tumor with high morbidity and mortality. We acquired miR-338-5p, which suppresses the development of glioma, from the GEO and CGGA databases. In addition, we predicted that hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 could relieve the silencing of IKBIP by miR-338-5p. By analyzing genes related to IKBIP expression, possible pathways affecting glioma were identified. This study provides new ideas for investigating multiple circRNAs in ceRNAs.