Research Paper Volume 13, Issue 23 pp 25138—25152
LncRNA SNHG3 promotes gastric cancer cell proliferation and metastasis by regulating the miR-139-5p/MYB axis
- 1 Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China
- 2 Qinggang Senior Care Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- 3 Department of Gastroenterology, Bishan Hospital of Chongqing, Chongqing 402760, China
- 4 Chongqing Public Health Medical Center, Chongqing 400036, China
- 5 Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Received: July 15, 2021 Accepted: November 23, 2021 Published: December 13, 2021
https://doi.org/10.18632/aging.203732How to Cite
Copyright: © 2021 Xie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The long non-coding RNA (lncRNA) SNHG3 has been shown to play oncogenic roles in several cancer types, but the mechanisms underlying its activity are poorly understood. In this study, we aimed to explore the clinical relevance and mechanistic role of SNHG3 in gastric cancer (GC). We found that SNHG3 expression in GC cell lines and tissues was significantly increased, and the upregulation of this lncRNA was correlated with tumor clinical stage and decreased patient survival. Knocking down SNHG3 in GC cells impaired the proliferative, migratory, and invasive activity in vitro and constrained in vivo GC xenograft tumor growth. Mechanistically, SNHG3 was found to bind and sequester miR-139-5p, thereby indirectly promoting the upregulation of the miR-139-5p target gene MYB. These data demonstrated that SNHG3 functions in an oncogenic manner to drive GC proliferation, migration, and invasion by regulating the miR-139-5p/MYB axis.