Research Paper|Volume 13, Issue 7|pp 10468—10489

Global, regional, and national burdens of leukemia from 1990 to 2017: a systematic analysis of the global burden of disease 2017 study

Xiangjie Lin^1,^2,³, Jinghan Wang^1,^2,³, Xin Huang^1,^2,³, Huafeng Wang^1,^2,³, Fenglin Li^1,^2,³, Wenle Ye^1,^2,³, Shujuan Huang⁴, Jiajia Pan^1,^2,³, Qing Ling^1,^2,³, Wenwen Wei^1,^2,³, Shihui Mao^1,^2,³, Yu Qian^1,^2,³, Jie Jin^1,^2,^3,⁵, Jiansong Huang^1,^2,³

¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
²Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Hangzhou, Zhejiang, China
³Institute of Hematology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⁴Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China
⁵Zhejiang University Cancer Center, Hangzhou, Zhejiang, China

Received: August 2, 2020Accepted: February 23, 2021Published: April 4, 2021

https://doi.org/10.18632/aging.202809

Copyright: © 2021 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We described the spatial and temporal trends of the annual leukemia incidence, prevalence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2017. Leukemia case numbers and age-standardized rates (ASRs) were extracted from the Global Burden of Disease (GBD) study 2017. The estimated annual percentage change (EAPC) in the ASR was calculated using a generalized linear model with a Gaussian distribution. The risk factors for death and DALYs due to leukemia were estimated within the comparative risk assessment framework of the GBD study. Globally, the prevalence, age-standardized prevalence rate (ASPR), and EAPC in leukemia cases in 2017 were 2.43 (95% uncertainty interval (UI) 2.19 to 2.59) million, 32.26 (95% UI 29.02 to 34.61), and 0.22% (95% CI 0.13 to 0.31, P<0.01), respectively, during 1990-2017. The trends of the age-standardized incidence, deaths, and DALY rate all significantly decreased globally. The burden of leukemia was higher in males than in female. An increasing leukemia burden was found in high-middle-sociodemographic index (SDI) countries and territories. The burden of leukemia tended to be lower in high-SDI regions than that in lower SDI regions. The rapid increases in the prevalent cases and prevalence rate of leukemia is urgent to be solved in the future.