Research Paper Volume 13, Issue 7 pp 9948—9959
Evaluation of gliomas peritumoral diffusion and prediction of IDH1 mutation by IVIM-DWI
- 1 Medical Imaging Center, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
- 2 Department of Radiology, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang Province, China
Received: December 11, 2020 Accepted: February 18, 2021 Published: March 26, 2021
https://doi.org/10.18632/aging.202751How to Cite
Copyright: © 2021 Gu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Glioma characterized by high morbidity and mortality, is one of the most common brain tumors. The application of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in differentiating glioma grading and IDH1 mutation status were poorly investigated. 78 glioma patients confirmed by pathological and imaging methods were enrolled. Glioma patients were measured using IVIM-DWI, then related parameters such as cerebral blood flow (CBF), perfusion fraction (f), pseudo diffusivity (D*), and true diffusivity (D), were derived. Receiver operating characteristic (ROC) curves were made to calculate specificity and sensitivity. The values of CBF1, CBF3, D*1, rCBF1-2, rCBF3-2, and age in group high-grade gliomas (HGG) were significantly higher than that of in group low-grade gliomas (LGG). The values of CBF1, CBF3, rCBF1-2, rCBF3-2, D*1, and age in group IDH1mut were significantly lower than that of in group IDH1wt. The levels of D1 and f1 were remarkably higher in the group IDH1mut than group IDH1wt. rCBF1-2 had a remarkably positive correlation with CBF1 (r=0.852, p<0.001). f1 showed a markedly negative correlation with CBF1 (r= -0.306, p=0.007). IVIM-DWI presented efficacy in differentiating glioma grading and IDH1 mutation status.
Abbreviations
IVIM-DWI: Intravoxel incoherent motion diffusion weighted imaging; 3D pCASL: Three-dimensional pseudo-continuous arterial spin labeling; CBF: Cerebral blood flow; f: Perfusion fraction; D*: Pseudo diffusivity; D: True diffusivity; HGG: High-grade gliomas; LGG: Low-grade gliomas; ASL: Arterial spin labeling; ROC: Receiver operating characteristic curve; T1WI: T1 weighted imaging; T2WI: T2 weighted imaging; MRI: Magnetic resonance imaging; NADPH: Nicotinamide adenine dinucleotide phosphate; IDH1mut: IDH1 mutation; IDH1wt: IDH1 wild-type; ICC: Intraclass coefficient.