Research Paper|Volume 13, Issue 6|pp 8396—8407

Comparison of VerifyNow, thromboelastography, and PL-12 in patients with minor ischemic stroke or transient ischemic attack

Lin Ma^1,^2,³, Weiqi Chen^1,^2,³, Yuesong Pan^1,^2,³, Hongyi Yan^1,^2,³, Hao Li^1,^2,³, Xia Meng^1,^2,³, Yongjun Wang^1,^2,³, Yilong Wang^1,^2,³

¹Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
²China National Clinical Research Centre for Neurological Diseases (NCRC-ND), Beijing, China
³Advanced Innovation Centre for Human Brain Projection, Capital Medical University, Beijing, China

* Equal contribution

Received: July 22, 2020Accepted: September 29, 2020Published: March 3, 2021

https://doi.org/10.18632/aging.202650

Copyright: © 2021 Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

High on-treatment platelet reactivity (HOPR) is associated with stroke recurrence. It is important to find a reliable method to assess HOPR. We aimed to compare the correlations between VerifyNow™ system, thromboelastography (TEG), and Aggrestar platelet function analyzer (PL-12) on platelet activity in patients with minor ischemic stroke or transient ischemic attack (TIA) after dual antiplatelet therapy for 7 days. About 276 patients were included. Spearman’s correlation coefficient and the kappa coefficient were adopted to evaluate associations among the three test methods. An obvious correlation between VerifyNow and TEG on HOPR-ADP (r=0.64, p<0.001) was found. The correlations of HOPR-ADP between PL-12 and the other two platelet function analyzers were moderate (PL-12 versus VerifyNow, r=0.47, p<0.001; PL-12 versus TEG, r=0.25, p<0.001). The correlations of HOPR-AA were limited among these three platelet function analyzers (VerifyNow versus TEG, r=0.09, p=0.14; VerifyNow versus PL-12, r=0.15, p=0.01; PL-12 versus TEG, r=0.10, p=0.09). Correlations among different platelet function analyzers were varied. VerifyNow and TEG were more correlative than PL-12 on HOPR-ADP. The consistence of HOPR-AA was limited among VerifyNow, TEG and PL-12. The proportion of stroke recurrence and composite events in patients with HOPR-ADP assessing by PL-12 was higher than VerifyNow and TEG.