Aging
Navigate
Submit an Article
Research Paper|Volume 13, Issue 6|pp 8146—8154

Early-onset of type 2 diabetes mellitus is a risk factor for diabetic nephropathy progression: a biopsy-based study

Yucheng Wu1,2, Yiting Wang1,2, Junlin Zhang1,2, Rui Zhang1,2, Lijun Zhao1,2, Honghong Ren1,2, Yutong Zou1,2, Tingli Wang1,2, Jiali Wang1,2, Yuancheng Zhao1,2, Chunmei Qin1,2, Huan Xu3, Lin Li3, Zhonglin Chai4, Mark E. Cooper4, Nanwei Tong5, Fang Liu1,2
  • 1Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
  • 2Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
  • 3Division of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
  • 4Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia
  • 5Division of Endocrinology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Received: October 12, 2020Accepted: January 22, 2021Published: March 3, 2021
https://doi.org/10.18632/aging.202624

Copyright: © 2021 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Several studies show that patients with early-onset diabetes have higher risk of diabetic complications than those diagnosed in middle age. However, whether early-onset of type 2 diabetes mellitus (T2DM) is a risk factor for diabetic nephropathy (DN) progression remains unclear, especially a lack of data in biopsy-confirmed cohort. In This study, we enrolled 257 patients with T2DM and biopsy-confirmed DN to investigate the role of early-onset T2DM in DN progression. Participants were divided into two groups according to the age of T2DM diagnosis: early-onset group (less than 40 years) and later-onset group (40 years or older). We found that patients with early-onset T2DM had higher glomerular grades and arteriolar hyalinosis scores than those in later-onset group. After adjusted for confounding factors, early-onset of T2DM remained an independent predictor of end-stage renal disease (ESRD) for patients with DN. In conclusion, although with the comparable renal function and proteinuria, patients with early-onset T2DM and DN had worse renal pathological changes than those with later-onset. Early-onset of T2DM might be an important predictor of ESRD for patients with DN, which called more attention to early supervision and prevention for patients with early-onset T2DM and DN.