Research Paper Volume 12, Issue 20 pp 20645—20657
Hsa_circ_0081534 increases the proliferation and invasion of nasopharyngeal carcinoma cells through regulating the miR-508-5p/FN1 axis
- 1 Department of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
- 2 Department of Otorhinolaryngology, Weihai Central Hospital, Weihai 264400, Shandong, China
Received: June 19, 2020 Accepted: July 30, 2020 Published: October 20, 2020
https://doi.org/10.18632/aging.103963How to Cite
Copyright: © 2020 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Accumulating lines of evidence indicate that circular RNAs (circRNAs) are involved in the pathogenesis of human cancers, including nasopharyngeal carcinoma (NPC). However, the influences of hsa_circ_0081534 upon the pathogenesis and dynamics of NPC are undescribed. In this study, we identified a circRNA hsa_circ_0081534 was significantly upregulated in NPC tissues and cell lines. Inhibition of hsa_circ_0081534 induced a decrease in NPC cells proliferation and invasion in vitro, and repressed tumor growth in vivo. In mechanism, hsa_circ_0081534 promoted NPC progression by sponging miR-508-5p. Fibronectin 1 (FN1) is a target gene of miR-508-5p. In addition, rescue assays showed that FN1 overexpression (or miR-508-5p inhibitors) abolished the roles of hsa_circ_0081534 inhibition on NPC cells proliferation and invasion. Therefore, hsa_circ_0081534 promoted the proliferation, and invasion of NPC cells via regulating the miR-508-5p/FN1 axis. Our findings suggested that hsa_circ_0081534 could be a novel therapeutic target for the treatment of NPC patients.