Aging
Navigate
Submit an Article
Research Paper|Volume 12, Issue 20|pp 19867—19879

CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients

Mingming Jin1, Nannan Shi2, Meng Wang1, Chunzi Shi1, Shengjie Lu1, Qing Chang3, Shuang Sha3, Yun Lin4, Yingmin Chen3, Hui Zhou3, Kaiyi Liang3, Xuyuan Huang3, Yuxin Shi2, Gang Huang1
  • 1Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
  • 2Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
  • 3Key Laboratory of Molecular Imaging, Jiading Central Hospital, Shanghai University of Medicine and Health Sciences, Shanghai 201800, China
  • 4Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
* Co-first authors
Received: June 24, 2020Accepted: July 30, 2020Published: October 16, 2020
https://doi.org/10.18632/aging.103941

Copyright: © 2020 Jin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The ongoing outbreak of COVID-19 has been announced by the World Health Organization as a worldwide public health emergency. The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. The results showed that the mortality of COVID-19 patients increased accompanied by age. Host factors CRP, IL-1β, hs-CRP, IL-8, and IL-6 levels in severe pneumonia patients were higher than in non-severe patients. CD3, CD8, and CD45 counts were decreased in COVID-19 patients. The results of this study suggest that the K-values of CD45 might be useful in distinguishing between severe and non-severe cases. The cut-off value for CD45 was -94.33. The K-values for CD45 in non-severe case were above the cut-off values, indicating a 100% prediction success rate for severe and non-severe cases following SARS-CoV-2 infection. The results confirmed that immune system dysfunction is a potential cause of mortality following COVID-19 infection, particularly for the elderly. CD45 deficiency dysfunction the naïve and memory T lymphocytes which may affects the long-term effectiveness of COVID-19 vaccines. K-values of CD45 might be useful in distinguishing between severe and non-severe cases in the early infection. May be CD45 could increase the diagnostic sensitivity.