Review|Volume 12, Issue 22|pp 23379—23393

Radiation-induced skin injury: pathogenesis, treatment, and management

Xiaojing Yang¹, Hanru Ren², Xiaomao Guo^3,⁴, Chaosu Hu^3,⁵, Jie Fu¹

¹Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
²Department of Orthopedics, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai, China
³Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
⁴Shanghai Medical College, Fudan University, Shanghai, China
⁵Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

* Equal contribution

Received: May 10, 2020Accepted: July 30, 2020Published: November 16, 2020

Copyright: © 2020 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Radiation-induced skin injury (RSI) refers to a frequently occurring complication of radiation therapy. Nearly 90% of patients having received radiation therapy underwent moderate-to-severe skin reactions, severely reducing patients' quality of life and adversely affecting their disease treatment. No gold standard has been formulated for RSIs. In the present study, the mechanism of RSI and topical medications was discussed. Besides, this study can be referenced for clinicians to treat RSIs to guide subsequent clinical medicine.