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Research Paper|Volume 12, Issue 15|pp 15260—15280

The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population

Yuxia Li1, Shaochen Guan2,3, He Jin4, Hongjun Liu2,3, Meimei Kang1, Xiaozhen Wang1, Can Sheng5, Yu Sun5, Xuanyu Li5, Xianghua Fang2,3, Rong Wang1,3,6
  • 1Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • 2Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • 3Beijing Geriatric Medical Research Center, Beijing 100053, China
  • 4Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin 541001, China
  • 5Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • 6Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China
Received: October 25, 2019Accepted: May 1, 2020Published: July 31, 2020
https://doi.org/10.18632/aging.103356

Copyright © 2020 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is elevated in early Alzheimer's disease (AD) and mild cognitive impairment, and is considered a biomarker for the early diagnosis of AD. However, it has not yet been investigated whether urinary AD7c-NTP is elevated with increases in blood biochemical indicators related to AD risk factors. We recruited 2180 participants, aged 35–93 years, from communities of four districts in Beijing. Blood biochemical indicators, including blood glucose, blood lipids, renal function, and high-sensitivity C-reactive protein, were measured using routine methods. Urinary AD7c-NTP was detected using an enzyme-linked immunosorbent assay AD7c-NTP kit. In the general population, there were no significant differences in urinary AD7c-NTP levels in subjects with different Mini–Mental State Examination levels or C-reactive protein values. After adjusting for age and sex, there were significant differences in urinary AD7c-NTP levels between different education levels, marital statuses, blood glucose, blood lipids, and kidney function. There was a negative correlation between urinary AD7c-NTP levels and serum creatinine (r = –0.128). There was a positive correlation between urinary AD7c-NTP levels and HbA1c (r = 0.104), insulin (r = 0.101), and triglycerides (r = 0.093). Urinary AD7c-NTP might be useful as a potential indicator to predict AD risk.