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Research Paper|Volume 12, Issue 5|pp 4348—4356

Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling

Xiangbin Wang1, Ding Ding2, Qianhua Zhao2, Xiaoniu Liang2, Ling Peng3, Xiaohu Zhao4, Qian Xi5, Zhang Min1, Wei Wang1, Xiaowen Xu1, Qihao Guo6, Pei-Jun Wang1
  • 1Department of Radiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, PR China
  • 2Institute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, PR China
  • 3Department of Radiology, Shanghai Liqun Hospital, Shanghai 200333, PR China
  • 4Department of Radiology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, PR China
  • 5Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, PR China
  • 6Department of Geriatrics, The Sixth People's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 200233, PR China
Received: September 5, 2019Accepted: February 22, 2020Published: March 12, 2020
https://doi.org/10.18632/aging.102888

Copyright © 2020 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We used pulsed arterial spin labeling (PASL) to investigate differences in cerebral blood flow (CBF) between 26 patients with amnestic mild cognitive impairment (aMCI) and 27 controls with normal cognition (NC). Hypoperfusion was observed in the right temporal pole of the middle temporal gyrus and the right inferior temporal gyrus in the aMCI compared with NC group. Interestingly, hyperperfusion was observed in the left temporal pole of the middle temporal gyrus, left superior temporal gyrus, bilateral precuneus, postcentral gyrus, right inferior parietal lobule, and right angular gyrus in the aMCI group, which likely resulted from a compensatory mechanism to maintain advanced neural activities. We found that mean CBF in the right inferior temporal gyrus, precuneus, and postcentral gyrus was positively correlated with cognitive ability in the aMCI but not NC group. Collectively, our data indicate that PASL is a useful noninvasive technique for monitoring changes in CBF and predicting cognitive decline in aMCI.