Aging
Navigate
Submit an Article
Research Paper|Volume 11, Issue 23|pp 11073—11083

Clinical and neuroimaging correlates among cohorts of cerebral arteriostenosis, venostenosis and arterio-venous stenosis

Jiayue Ding1,2,3, Jingwei Guan1,2,3, Gary Rajah4,5, David Dornbos III6, Weili Li1,2,3, Zhongao Wang1,2,3, Yuchuan Ding3,7, Xunming Ji2,3,8, Ran Meng1,2,3
  • 1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
  • 2Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
  • 3Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China
  • 4Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA
  • 5Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY 14203, USA
  • 6Department of Neurological Surgery, Semmes-Murphey Clinic and the University of Tennessee Health Science Center, Memphis, TN 38103, USA
  • 7Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
  • 8Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
Received: August 19, 2019Accepted: November 18, 2019Published: December 2, 2019
https://doi.org/10.18632/aging.102511

Copyright © 2019 Ding et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The purpose of this study was to discriminate the clinical and imaging correlates of cerebral arterial stenosis (CAS), venous stenosis (CVS) and arterio-venous stenosis (CAVS) in the clinical setting. Patients were classified into three groups: CAS (n = 75), CVS (n=74) and CAVS (n=67). Focal neurological deficits were the prominent presenting symptoms in CAS group, while venous turbulence related symptoms were common in both CVS and CAVS group. Risk factor analysis showed the OR (95%CI) for diabetes, male gender and age in CAS vs. CVS group were 13.67(2.71, 68.85), 6.69(2.39, 18.67) and 1.07(1.03, 1.12) respectively. Male gender, diabetes and age in CAVS vs. CAS groups were 0.27(0.11, 0.63), 0.26(0.10, 0.67) and 1.09(1.04, 1.14) respectively, while age in CAVS vs. CVS group was 1.11(1.07, 1.15). The white matter lesions (WMLs) in CAS group varied in size, with clear boundaries asymmetrically distributed in bilateral hemispheres. CVS-induced WMLs revealed a bilaterally symmetric, cloudy-like appearance. The cerebral perfusion was asymmetrically reduced in CAS but symmetrically reduced in CVS group. The clinical characteristics and neuroimaging presentations were different among patients with CAS, CVS and CAVS. We recommended for aged patients, both arterial and venous imaging should be considered in diagnosis of cerebral stenotic vascular disorders.