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Research Paper|Volume 11, Issue 8|pp 2447—2456

Association between plasma macrophage migration inhibitor factor and deep vein thrombosis in patients with spinal cord injuries

Dong-Mei Wu1,2, Zi-Hui Zheng3, Shan Wang1,2, Xin Wen1,2, Xin-Rui Han1,2, Yong-Jian Wang1,2, Min Shen1,2, Shao-Hua Fan1,2, Zi-Feng Zhang1,2, Qun Shan1,2, Meng-Qiu Li1,2, Bin Hu1,2, Yuan-Lin Zheng1,2, Gui-Quan Chen4, Jun Lu1,2
  • 1Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou, P.R. China
  • 2College of Health Sciences, Jiangsu Normal University, Xuzhou, P.R. China
  • 3State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, P.R. China
  • 4State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, P.R. China

* * Equal contribution

Received: February 11, 2019Accepted: April 23, 2019Published: April 29, 2019
https://doi.org/10.18632/aging.101935

Copyright: Wu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The patients with spinal cord injury (SCI) suffered significantly higher risk of deep vein thrombosis (DVT) than normal population. The aim was to assess the clinical significance of macrophage migration inhibitory factor (MIF) as the risk factor for DVT in acute SCI patients. 207 Chinese patients were enrolled in this study, including thirty-nine (39) patients (18.8 %; 95 %CI: 13.5 %–24.2 %) diagnosed as DVT at the follow-up of 1 month. Nine (9) of the 39 patients (23.1%) were suspected of thrombosis before the screening. The MIF levels in plasma of DVT patients were significantly higher than DVT-free patients. The risks of DVT would be increased by 11 % (OR unadjusted: 1.11; 95% CI, 1.06–1.17, P<0.001) and 8 % (OR adjusted: 1.08; 1.03–1.14, P=0.001), for each additional 1 ng/ml of MIF level. Furthermore, after MIF was combined with established risk factors, area under the receiver operating characteristic curve (standard error) was increased from 0.82(0.035) to 0.85(0.030). The results showed the potential association between the high MIF levels in plasma and elevated DVT risk in SCI patients, which may assist on early intervention.