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Research Paper|Volume 11, Issue 7|pp 2031—2044

Exogenous biological renal support ameliorates renal pathology after ischemia reperfusion injury in elderly mice

Dong Liu1,2, Zhiwei Yin1, Qi Huang1,3, Yi Ren1, Diangeng Li1, Linna Wang1, Shaoyuan Cui1, Ying Zhang1, Yichun Ning1,4, Lide Lun2, Guangyan Cai1, Xueyuan Bai1, Xuefeng Sun1, Xiangmei Chen1
  • 1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • 2Department of Nephrology, Air Force Medical Center, PLA, the Fourth Military Medical University, Beijing 100142, China
  • 3Department of Nephrology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • 4Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Received: August 1, 2018Accepted: March 31, 2019Published: April 12, 2019
https://doi.org/10.18632/aging.101899

Copyright: Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We established an exogenous biological renal support model through the generation of parabiotic mice. At 72 hours after ischemia reperfusion injury (IRI), the aged mice that received exogenous biological renal support showed significantly higher levels of renal cell proliferation and dedifferentiation, lower levels of renal tubular injury, improved renal function, and a lower mortality than those that did not receive exogenous biological renal support. Using the Quantibody Mouse Cytokine Antibody Array, we found that aged IRI mice that received exogenous biological renal support had an up-regulation of multiple inflammatory related cytokines compared to the group that did not receive exogenous biological renal support. We suggest that the exogenous biological renal support might promote renal tubular epithelial cell proliferation and dedifferentiation and improve the prognosis of aged IRI mice. Exogenous biological renal support may play an important role in the amelioration of renal IRI by regulating the expression of multiple cytokines.