Research Paper|Volume 11, Issue 5|pp 1524—1536

Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia

Katarzyna Grzesiak¹, Aleksandra Rył², Weronika Ratajczak¹, Ewa Stachowska³, Iwona Rotter², Marcin Słojewski⁴, Olimpia Sipak⁵, Kinga Walczakiewicz¹, Maria Laszczyńska¹

¹Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin 71-210, Poland
²Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Szczecin 71-210, Poland
³Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin 71-460, Poland
⁴Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin 70-111, Poland
⁵Department of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University, Szczecin 71-210, Poland

Received: November 15, 2018Accepted: March 3, 2019Published: March 13, 2019

https://doi.org/10.18632/aging.101850

Copyright: © 2019 Grzesiak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The purpose of our investigation was to analyze the relationship between the serum levels of fatty acids and their metabolites and the levels of the selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). We determined serum concentrations of total (TT) and free testosterone (FT), insulin (I), dehydroepiandrosterone sulphate (DHEAS), luteinizing hormone and insulin-like growth factor 1 (IGF-1) and sex hormone-binding globulin (SHBG). Gas chromatography was performed. The patients differed in terms of hormone levels, but only the differences in SHBG and IGF-1 levels were statistically significant. Analysis of the levels of polysaturated fatty acids in BPH patients showed that MetS contributed to changes in the levels of these acids. We also analyzed the relationship between the levels of fatty acids and diagnostic parameters for MetS. Particular abnormalities were associated with single changes in the levels of fatty acids. In the diabetic patients, changes in the levels of pentadecanoic acid, heptadecanoic acid and cis-11-eicosenoic acid were demonstrated. Our findings indicate the necessity for further investigation concerning the levels of fatty acids and their impact on the development of MetS, as well as the course and clinical picture of BPH.