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Research Paper|Volume 11, Issue 4|pp 1129—1150

Stem cell-derived extracellular vesicles for myocardial infarction: a meta-analysis of controlled animal studies

Lihong Yang1,2, Jialu Zhu2, Cong Zhang3, Juntao Wang4, Fengyang Yue2, Xingtai Jia5, Hongzhi Liu2,6,7
  • 1Department of Cardiac Function Evaluation, Henan Provincial People’s Hospital, Zhengzhou, Henan, China
  • 2Department of Cardiology, Zhengzhou University People’s Hospital, Zhengzhou, Henan, China
  • 3Department of Electrocardiology, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China
  • 4Department of Cardiology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China
  • 5Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
  • 6Department of Cardiology, Fuwai Central China Hospital, Zhengzhou, Henan, China
  • 7Department of Cardiology, Henan Provincial People’s Hospital, Zhengzhou, Henan, China

* * Equal contribution

Received: October 7, 2018Accepted: February 1, 2019Published: February 21, 2019
https://doi.org/10.18632/aging.101814

Copyright: © 2019 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aims

Stem cell-derived extracellular vesicles (EVs) have emerged as a promising therapy for myocardial infarction, but its effects remain incompletely understood. We aim to systematically review the efficacy of EVs on myocardial infarction in both small and large animals.

Methods

On April 5, 2018, we searched the PubMed, Embase and Web of Science databases using variations of “myocardial infarction” and “extracellular vesicle”. Controlled studies about the treatment effects of stem cell-derived EVs in myocardial infarction animal model were included. Meta-regression analysis was used to reveal the factors affecting the EVs treatments.

Results

Of 1210 studies retrieved, 24 were eligible for meta-analysis. EVs injection was associated with the improvements of left ventricular ejection fraction (12.65%), fractional shortening (7.54%) and the reduction of infarct size/area at risk (-15.55%). Meta-regression analysis did not reveal the association between treatment efficacy and type of stem cell, ligation-to-injection interval, route of delivery, dosage of delivery or follow-up period (all P values > 0.05). The median quality score of eligible studies was only 1, indicating potential risks of bias.

Conclusion

Stem cell-derived EVs improve cardiac function and reduce infarct size in myocardial infarction animals, but current pool-up study reveals no associations between common factors and treatment effects.